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KMID : 0604020140290030189
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Korean Journal of Critical Care Medicine
2014 Volume.29 No. 3 p.189 ~ p.193
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Patients with Acute Respiratory Distress Syndrome Caused by Scrub Typhus: Clinical Experiences of Eight Patients
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Kim Sun-Young
Jang Hang-Jae
Kim Hyun-Kuk
Shin Kyung-Hwa
Kim Mi-Hyun
Lee Kwang-Ha
Kim Ki-Uk
Park Hye-Kyung
Lee Min-Ki
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Abstract
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Background: The aim of this study is to describe the clinical course and outcome of patients who were diagnosed with acute respiratory distress syndrome (ARDS) caused by scrub typhus and who received ventilator care in the intensive care units (ICU) of two university hospitals.
Methods: We performed a retrospective analysis of all adult ventilated patients who were diagnosed with ARDS caused by scrub typhus.
Results: Eleven (1.7%) of 632 scrub typhus patients were diagnosed with ARDS (median age 72; seven were male). Eight patients had underlying diseases, the most common of which was hypertension (four patients). Eight patients (72.7%) were admitted in November. The most common chief complaints of the patients were fever and rash (63.6%). All patients had skin eschar and rash; seven were treated for shock. On the day of diagnosis with ARDS, the median Acute Physiology and Chronic Health Evaluation score was 20 (range 11-28) and Sequential Organ Failure Assessment score was 7 (range 4-14). All patients had PaO2/FiO2 < 200 mmHg, high serum aspartate aminotransferase level (> 40 IU/L), and hypoalbuminemia (< 3.3 g/dl). Nine patients were treated with doxycycline on the day of admission. Their median lengths of stay in the ICU and hospital were 10 (range 4-65) and 14 (4-136) days, respectively. The mortality rate during treatment in the hospital was 36.4%.
Conclusions: In our study, the risk of ARDS among patients diagnosed with scrub typhus was at least 1.7%, with a hospital mortality rate of 36.4%.
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KEYWORD
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acute respiratory distress syndrome, intensive care unit, scrub typhus
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